CONTACT: Address; 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan Tel: +81-45-503-7037(Group Director) +81-45-503-7024 & 7038(Secretary) Fax: +81-45-503-7036 E-mail: saito@rcai.riken.jp EDUCATION: B.S. Author and Article Information Tadashi Yokosuka 1. Developed by Takashi Saito and Takaomi C. Saido, RIKEN Brain Science Institute in 2009. Google Scholar. Laminar distribution of Aβ plaques in the hippocampus of APP knock-in mice. Takashi Saito and Takaomi C. Saido, Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, 2‐1 Hirosawa, Wako‐city, Saitama 351‐0198, Japan. (15)Laboratory for Cell Signaling, WPI Immunology Frontier Research … Since 2004 Saito has been a group director at Laboratory for Cell Signaling of RIKEN Center for Integrative Medical Sciences. Also he worked as a professor at the same university from 1989 to 2004. C57BL/6 background. Amyloid-β (Aβ) is the major component of senile plaques in Alzheimer’s disease (AD) brains. Correspondence: Takashi Saito, Laboratory for Cell Signaling, RIKEN Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan Fax: +81-45-503-7036 e-mail: saito@rcai.riken.jp Received17/11/03 Revised 8/11/04 Accepted16/12/04 [DOI 10.1002/eji.200324746] … RIKEN, Japan. The use of monoclonal antibodies (mAbs) for cancer therapy has achieved significant success in recent years. Abstract … A floxed neo cassette was removed by crossing with EIIa-cre mice (B6.FVB-Tg(EIIa-cre)C5379Lmgd/J). Academic Profile User Profile. C57BL/6 background. Search for other works by this author on: This Site. This work was supported in part by research grants from the RIKEN Center for Brain Science, research grants from the RIKEN Aging Project, a Grant-in-Aid-for Scientific Research (B) from MEXT (to T. S.), Precursory Research for Embryonic Science and Technology from JST (to T. S.), the Cell Science Research … Tokyo Institute of Technology, Tokyo, Chemistry: M.S. Research Feed. He spent his first 13 seasons pitching for the Yokohama BayStars in the Japanese … Takashi Saito Curriculun Vitae. CORRESPONDENCE Tadashi Yokosuka yokosuka@rcai.riken.jp OR Takashi Saito saito@rcai.riken.jp. In Brief Toll-like receptor-2 (TLR2) directly stimulates effector, but not naı¨ve, T cells. C57BL/6 derived ES cells were used to generate the mutant mice. Strain description : App knock-in mice … Reviewed by Michael L. Dustin. 1 Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, 2-1 Hirosawa, Wako-City, Saitama, ... Nagoya-City, Aichi, 464-8601, Japan. Unit Leader: Takashi Saito (Ph.D.) Japanese Page; Research Summary. University of Oxford, United Kingdom. Takashi Saito 1 2 , Naomi Mihira 3 , Yukio Matsuba 3 , Hiroki Sasaguri 3 , Shoko Hashimoto 3 ... 2-1 Hirosawa, Wako-city, Saitama 351-0198, Japan takashi.saito.aa@riken.jp. The study was conducted jointly with Takaomi Saido, a team leader at the RIKEN and Professor Takashi Saito at Nagoya City University, as part of the JST Strategic Basic Research Programs. takashi.saito.aa@riken.jp. However, it is not clear why CBL has less Aβ deposition than CTX. Developed by Takashi Saito and Takaomi C. Saido, RIKEN Brain Science Institute in 2009. 5 Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan. … Senile plaques are generally observed in cerebral cortex (CTX) rather than cerebellum (CBL) in AD patients. Kenichi Nagata 1 , Takashi Saito 2 , Takaomi C Saido 3 , Takashi Morihara 4 Affiliations 1 Department of Precision Medicine for Dementia, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan; Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako, Saitama, Japan. 2 c-f. Quantification of the Aβ plaque load in hippocampal subfields and laminae of CA1, CA2/3 and dentate gyrus (DG) of sections from 2, 3, 4, and 6 month old APP NL-G-F/NL-G-F … Tel: +81‐48‐462‐1111 (Ext. takashi.saito@riken.jp. Search for more papers by … Linkage to RIKEN Program for Drug Discovery and Medical Technology Platforms (DMP) ... (Daiki Miki) and therapeutic mAb for IBD (Takashi Saito). 12 Laboratory for Cell Signaling, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan takashi.saito@riken.jp. C57BL/6 background. Takashi Saito, Naomi Mihira, Yukio Matsuba, Hiroki Sasaguri, Shoko Hashimoto, Sneha Narasimhan, Bin Zhang, Shigeo Murayama, Makoto Higuchi, Virginia M.Y. Research Feed My following Paper Collections. A floxed neo cassette was removed by crossing with EIIa-cre mice (B6.FVB-Tg(EIIa-cre)C5379Lmgd/J). Title: CV: Takashi Saito Author: Takashi Saito Created Date: 1/16/2013 11:38:32 AM Graphs detailing the data summarized in Fig. Loop is the open research network that increases the discoverability and impact of researchers and their work. Takashi SAITO of RIKEN, Wako (RIKEN AICS) | Read 302 publications | Contact Takashi SAITO Thereafter, RECIPIENT agrees to acknowledge Hiroki Sasaguri, Shoko HASHIMOTO, Takashi SAITO, and Takaomi C. SAIDO in an “acknowledgement” section, and does not need to co-author Hiroki Sasaguri, Shoko HASHIMOTO, Takashi SAITO, and Takaomi C. SAIDO. Electronic address: takashi.saito.aa@riken.jp. Emails: takashi.saito.aa@riken.jp, takaomi.saido@riken.jp This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Log in AMiner. Loop enables you to stay up-to-date with the latest discoveries and news, connect with researchers and form new collaborations. In 1988, Takashi took a position of an assistant professor at Chiba University. TABLE OF CONTENTS . Developed by Takashi Saito and Takaomi C. Saido, RIKEN Brain Science Institute in 2009. They show that TLR-associated … … Takashi Saito (斎藤 隆, Saitō Takashi), born February 14, 1970, is a retired Japanese professional baseball pitcher who last played for the Tohoku Rakuten Golden Eagles of Nippon Professional Baseball.. Saito's professional career spanned 23 years. ), takashi.saito@riken.jp (T.S.) RECIPIENT also agrees to cite the original publications [Saito … Strain description : App knock-in mice … The editor and reviewers' affiliations are the latest provided on their Loop research profiles and may not reflect their situation at the time of review. 1975. The preclinical study of the Artificial adjuvant vector cell project for cancer therapy has been completed and, therefore, Fujii et al. C57BL/6 derived ES cells were used to generate the mutant mice. McGill University, Canada. demonstrate the molecular mechanisms of TLR2-mediated T cell activation. C57BL/6 derived ES cells were used to generate the mutant mice. Takashi Saito To understand the molecular processes that link Aβ amyloidosis, tauopathy and neurodegeneration, we screened for tau-interacting proteins by immunoprecipitation/LC-MS. Loop is the open research network that increases the discoverability and impact of researchers and their work. Imanishi et al. Shin-ichi Muramatsu 3,4, Takaomi C. Saido 1 & Takashi Saito 1,5 To understand the molecular processes that link Aβ amyloidosis, tauopathy and neurode- generation, we screened for tau-interacting proteins by immunoprecipitation/LC-MS. We identified the carboxy-terminal PDZ ligand of nNOS (CAPON) as a novel tau-binding protein. Correspondence: takashi.saito@riken.jp; takayuki.imanishi@riken.jp Wakana Kobayashi’s present address is Laboratory for Mucosal Immunity, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. 2 Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Aichi 464-8601, Japan. Additional file 3: Figure S3. 3 Laboratory for Proteolytic Neuroscience, RIKEN … PubMed. Team Leader: Ken-ichi Masuda (Ph.D.) Deputy Team Leader: Takashi Saito (Ph.D.) Japanese Page; Research Summary. are preparing for an investigator-initiated … Electronic address: takaomi.saido@riken.jp. Takashi Saito takashi.saito@riken.jp Specialty section: This article was submitted to T Cell Biology, a section of the journal Frontiers in Immunology Received: 15 December 2015 Accepted: 15 June 2016 Published: 28 June 2016 Citation: Hashimoto-Tane A and Saito T (2016) Dynamic Regulation of TCR–Microclusters … View the profiles of professionals named "Takashi Saito" on LinkedIn. Takashi Saito. Vaccination is the effective method as protection from pathogenic infection and prevention of severe symptoms, which has been widely … Laboratory for Cell Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama, … (8)Laboratory for Cell Signaling, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan. Strain description : App knock-in mice … 6 Department of Neuropsychiatry, Keio University School of Medicine, 35 Shinanomachi, Shinjuku … 7615) Fax: +81‐48‐467‐9716. PMID: 31160584 PMCID: PMC6546774 DOI: 10.1038/s41467-019-10278-x Abstract To understand the molecular processes … Abstract; … Loop enables you to stay up-to-date with the latest discoveries and news, connect with researchers and form new collaborations. Update Photo. Our laboratory is developing antibody drugs for Gliomas, AML, B lymphomas and Hepatitis by collaborations within and outside of RIKEN … Shizuo Akira, Takashi Saito Correspondence takayuki.imanishi@riken.jp (T.I. views: 2. RIKEN Baton Zone Program Vaccine Innovation Laboratory. Received: 1 August 2018; accepted: 19 August 2018. A floxed neo cassette was removed by crossing with EIIa-cre mice (B6.FVB-Tg(EIIa-cre)C5379Lmgd/J). Emails: takashi.saito.aa@riken.jp, takaomi.saido@riken.jp. There are 100+ professionals named "Takashi Saito", who use LinkedIn to exchange information, ideas, and opportunities. Finding a way to lower Aβ levels is fundamental for the prevention and treatment of AD. Takayuki Hoshii’s present address is Department of Pediatric Oncology, Dana-Farber Cancer Institute and Division of … Takashi Saito. Neprilysin is the major Aβ degrading enzyme which is regulated … Michel L. Tremblay. (9)Cell Signaling, Immunology Frontier Research Center, Osaka University, Suita, Osaka 565 … Footnotes. Follow . Takashi Saito, RIKEN Brain Science Institute, Wako-shi, Saitama, Japan, undefined... Home Research-feed Channel Rankings GCT THU AI TR Open Data Must Reading. Sign … Alzheimer’s disease (AD) brains are characterized by increased levels of the pathogenic amyloid beta (Aβ) peptide, which accumulates into extracellular plaques. (14)Laboratory for Cell Signaling, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan takashi.saito@riken.jp. RIKEN Center for Integrative Medical Sciences Drug Discovery Antibody Platform Unit. Finding a way to lower Aβ levels is fundamental for the prevention and treatment of AD August 2018 CBL... 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