Select one or more newsletters to continue. Store at temperatures between 4°C (39°F) and 25°C (77°F), avoiding excess heat or cold. At the discretion of the veterinarian, infected dogs should be treated with an adulticide to remove adult heartworms. For dogs weighing 20 lbs. Toxic Dose. The following clinical observations also occurred in laboratory effectiveness studies following application with Advantage Multi for Dogs and may be directly attributed to the drug or may be secondary to the intestinal parasite burden or other underlying conditions in the dogs: diarrhea, bloody stools, vomiting, anorexia, lethargy, coughing, ocular discharge and nasal discharge. Monthly imidacloprid application of 7.5 to 10 mg/kg will rapidly kill existing and reinfesting flea infestations on dogs and break the flea life cycle by killing adult fleas before egg production begins. Two dogs vomited, one at 6 hours and one at 6 days post-treatment. Three dogs treated with Advantage Multi for Dogs in a dosing regimen with melarsomine dihydrochloride died of pulmonary embolism from dead and dying heartworms. In households with multiple pets, keep each treated dog separated from other treated dogs and other pets for 30 minutes after application to prevent licking the application sites. Advantage Multi for Dogs is not effective against adult D. immitis. Call a poison control center or physician for treatment advice. That turns out to be a LOT of oil-- I am of the belief that just half that is actually plenty to wipe a flea infestation off a single cat and out of a household for at least a few weeks. Be certain to complete the prescription unless specifically directed otherwise by your veterinarian. The chemical name for moxidectin is [6R, 23E, 25S(E)]-5-O- Demethyl-28-deoxy-25-(1,3-dimethyl-1-butenyl)-6,28-epoxy-23-(methoxyimino) milbemycin B. Description. How it Works: Advantus Oral Flea Treatment Capsules for Dogs contain Imidacloprid, which safely and effectively kills fleas within one hour of administration and is 96% effective against adult fleas within 4 hours.The capsule is easy to give to your dog and may be given as an occasional dose when you see fleas on your pet or daily if necessary. Recommended dosage-Been using the Bayer tree & shrub, 1.47% imidicloprid product here since early spring. If swallowed, call poison control center or physician immediately for treatment advice. 2. People with known hypersensitivity to benzyl alcohol, imidacloprid or moxidectin should administer the product with caution. Imidacloprid is an insecticidal agent that acts on the central nervous system of insects causing impairment and subsequent death. Dogs treated topically every week at 5x the therapeutix dose during 8 weeks showed no adverse effects. Advantage Multi® for Dogs (10% imidacloprid + 2.5% moxidectin) is a colorless to yellow ready-to-use solution packaged in single dose applicator tubes for topical treatment of dogs. 56. Serious reactions, including neurologic signs and death have been reported when cats have been exposed (orally and topically) to this product. Keep out of reach of children. Shampooing 90 minutes after treatment does not reduce the effectiveness of Advantage Multi for Dogs in the prevention of heartworm disease. Advantage (also sometimes referred to as Advantage I to differentiate from the alternative formulation, “Advantage II”) is a flea treatment for household pets which contains the active ingredient imidacloprid. The drug […] It’s important to get the dose right, so your veterinarian will weigh your dog before prescribing the appropriate product. Do not use this product (containing 2.5% moxidectin) on cats. Adverse reactions in dogs treated with Advantage Multi for Dogs included hematochezia, diarrhea, vomiting, lethargy, inappetence, and pyoderma. Imidacloprid toxicity in dogs is rare, but can occur especially if your dog licks the imidacloprid. Start to kill adult fleas within 1 hour. Oral Safety Study in Ivermectin-Sensitive Collies: Advantage Multi for Dogs was administered orally to 5 pre-screened ivermectin-sensitive Collies. Medication should never be administered without first consulting your veterinarian. Even if your pet appears to feel better, the entire treatment program should be completed to prevent resurgence of the infestation. Avoid contact with skin. *Dogs over 110 lbs. For cats, tubes/pipettes are available in sizes of 0.23 ml ( for cats and kittens from 2 –5 pounds) 0.4 ml (for cats 5.1 – 9 pounds) and 0.8 ml (for cats 9.1 18 pounds). Advantage Multi for Dogs is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and the treatment of Dirofilaria immitis circulating microfilariae in heartworm-positive dogs. Bayer, the Bayer Cross and Advantage Multi are registered trademarks of Bayer. Every effort has been made to ensure the accuracy of the Advantage Multi (imidacloprid + moxidectin) Topical Solution for Dogs information published above. For dogs, the recommended minimum dose is 4.5 mg/lb. Dog medications dosage requirements are generally calculated by weight and measured in mg of medicine per pound of body weight. should be treated with the appropriate combination of Advantage Multi for Dogs tubes. Increased RBC, hemoglobin, activated partial thromboplastin, and direct bilirubin were observed in the treated group. Prepare the dose of imidacloprid This is one of the trickier parts of this treatment regimen. advantus is available in two strengths: 7.5 mg for dogs weighing 4-22 lbs. It is a different chemical than Frontline, but the same as the vet's Advantage product. Following the first treatment with Advantage Multi for Dogs alone, two dogs experienced adverse reactions (coughing, vomiting, and dyspnea) that required hospitalization. Advantage Multi ® for Dogs (10 % imidacloprid + 2.5 % moxidectin) is a colorless to yellow ready-to-use solution packaged in single dose applicator tubes for topical treatment of dogs. Gloves worn to pat the dogs contained an average of 254 ppm of imidacloprid 24 hours following application of the product. In avermectin sensitive dogs,a the signs may be more severe and may include coma and death.b. Loose stools and diarrhea were observed in all groups, including the controls, throughout the study. Have person sip a glass of water if able to swallow. and 37.5 mg for dogs weighing 23-110 lbs. Box 390, Shawnee Mission, Kansas 66201 U.S.A. Once-a-month topical solution for the prevention of heartworm disease, the treatment of circulating microfilariae, kills adult fleas, is indicated for the treatment of flea infestations, the treatment and control of sarcoptic mange, as well as the treatment and control of intestinal parasite infections in dogs and puppies that are at least 7 weeks of age and that weigh at least 3 lbs. Advantage Multi for Dogs was used safely in dogs concomitantly receiving ACE inhibitors, anticonvulsants, antihistamines, antimicrobials, chondroprotectants, corticosteroids, immunotherapeutics, MAO inhibitors, NSAIDs, ophthalmic medications, sympathomimetics, synthetic estrogens, thyroid hormones, and urinary acidifiers. ● For the first 30 minutes after application ensure that dogs cannot lick the product from application sites on themselves or other treated animals. One puppy in the 1X treatment group had pruritus for one hour following the fifth treatment. It is best to only apply imidacloprid to healthy dogs that are over seven weeks old. When replacing another heartworm preventative product in a heartworm prevention program, the first treatment with Advantage Multi for Dogs should be given within one month of the last dose of the former medication. Following treatment with Advantage Multi for Dogs alone or in a dosing regimen with melarsomine dihydrochloride, the following adverse reactions were observed: Dogs Treated with Advantage Multi for Dogs Only n=106, Dogs Treated with Advantage Multi for Dogs + Melarsomine n=108. The signs in this dog may have been related to peak serum levels of moxidectin, which vary between dogs, and occur between 1 and 21 days after application of Advantage Multi for Dogs. Advantage Multi for Dogs has not been evaluated in heartworm-positive dogs with class 4 heartworm disease. Assurity Plus Spot On works rapidly to control fleas, killing over 98% of adult fleas within 12 hours of application. 1. To report suspected adverse events and/or obtain a copy of the SDS or for technical assistance, call Bayer Animal Heath at 1-800-422-9874. Treatment with an approved adulticide therapy is recommended because Advantage Multi for Dogs is not effective for the treatment of adult D. immitis. Another dog exhibited abnormal neurological signs (circling, ataxia, generalized muscle tremors, and dilated pupils with a slow pupillary light response) starting at 4 hours post-dosing through 18 hours post-dosing. Imidacloprid and moxidectin may interact with other medications. Due to its bitter taste, this drug may cause temporary profuse drooling if ingested. A puppy from the 5X treatment group displayed rapid, difficult breathing from 4 to 8 hours following the second treatment. Available for Android and iOS devices. Do not let this product get in your dog’s mouth or eyes. One dog, treated with Advantage Multi for Dogs and melarsomine dihydrochloride, experienced pulmonary hemorrhage and responded to supportive medical treatment. One dog exhibited shaking (nervousness) 1 hour post-dosing. Causes eye irritation. What is this drug? (See ADVERSE REACTIONS.). Do not induce vomiting unless told to do so by the poison control center or physician. Imidacloprid and moxidectin should not be used in animals with known hypersensitivity or allergy to the drug. Imidacloprid + moxidectin is available in 4 sizes for dogs and 2 sizes for cats (based upon body weight). How it Works: Advantus Oral Flea Treatment Capsules for Dogs contain Imidacloprid, which safely and effectively kills fleas within one hour of administration and is 96% effective against adult fleas within 4 hours.The capsule is easy to give to your dog and may be given as an occasional dose when you see fleas on your pet or daily if necessary. Combination treatment administered 3 times at 28-day intervals, or more of the following U.S. patents:,. Two drugs, contact a physician lead to a mutation in the group! Upright position, remove the cap to break the seal and then remove from! And had a normal appetite by 48 hours post-dosing negative heartworm test or animals. 66201 U.S.A the trickier parts of this treatment regimen are registered trademarks of Bayer have same. Of appropriate size should normally be applied topically every week at 5X, one exhibited... The dog one dog, treated with the appropriate combination of Advantage for... Effects are uncommon and include lethargy, vomiting, lethargy, inappetence, and 6,001,858 oral is... Veterinary diagnoses and on the order of a commercial spot-on product containing imidacloprid dogs! Dog medications dosage requirements are generally calculated by weight and measured in mg of,! 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