A mechanism linking the risk ‘A’ allele in either case is not described, but it is possible to hypothesize that the risk ‘A’ allele results in reduced NOS3 activity which in turn leads to a reduction in NO production.
Manually curated information for which there is published experimental evidence.The risk ‘G’ allele of G51-898A in the NOS3 gene is associated with increased cardiovascular risk markers and increased risk of high blood pressure 5,6.
More information in the GO evidence code guide, Inferred from biological aspect of ancestor,
Inferred from Mutant PhenotypeCavia porcellus (Guinea pig) Status. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.
This subsection of the Names and taxonomy section provides information on the name(s) of the organism that is the source of the protein sequence.
This subsection of the Names and taxonomy section shows the unique identifier assigned by the NCBI to the source organism of the protein. Most of the dietary and lifestyle factors impact the function of eNOS independent of the NOS3 polymorphisms. All citations used have been vetted by our research team headed by Dr. Aaron Gardner. , A0S0A8, A8KA63, B2RCQ1, E9PFR2, Q13662, Q14251, Q14434, Q548C1, Q6GSL5,
This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)),
In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.
This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. Regulation of NOS3 dephosphorylation by protein phosphatase 2A is a key point for control of nitric oxide-dependent signaling pathways in vascular endothelial cells. SWISS-MODEL Repository - a database of annotated 3D protein structure models, Database of comparative protein structure models, Protein Data Bank in Europe - Knowledge Base, Relative evolutionary importance of amino acids within a protein sequence, evolutionary genealogy of genes: Non-supervised Orthologous Groups, Identification of Orthologs from Complete Genome Data, Database for complete collections of gene phylogenies, Gene3D Structural and Functional Annotation of Protein Families, Integrated resource of protein families, domains and functional sites, PIRSF; a whole-protein classification database, Protein Motif fingerprint database; a protein domain database, Superfamily database of structural and functional annotation, PROSITE; a protein domain and family database.
This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.
This subsection of the PTM / Processing section specifies the position(s) and the type of covalently attached lipid group(s).
Manually validated information inferred from a combination of experimental and computational evidence.Therefore, iron supplementation may benefit those at cardiovascular risk, especially those carrying the risk ‘A’ allele of A-52+1009T which is associated with elevated blood pressure. With the risk ‘T’ allele of T894G proposed to be associated with reduced NOS3 activity, supplementation with vitamin B2 may prove beneficial those with elevated blood pressure or who are at cardiovascular risk. Iron is a co-factor required by NOS3 in order to function correctly 9.
The Gene Ontology (GO) project provides a set of hierarchical controlled vocabulary split into 3 categories:
Inferred from Physical Interaction
An evidence describes the source of an annotation, e.g. Based on established evidence on the direct role of NF-κB in the regulation of NOS3 gene expression (7, 9, 12), we demonstrated that the increased p50 expression in I allele carriers and the resulting abundance of a NF-kB signaling pool interacts with chronic exercise, which induces hemodynamic shear stress and enhances NOS3 gene expression levels through the NF-κB-mediated signaling pathway. The functional relevance of NOS3 and ACE genetic variations to endothelial cell function is largely unstudied. Vitamin B2 is one of three co-factors required by NOS3 to function correctly 8. Among its related pathways are HIF1Alpha Pathway and Signaling by GPCR. Pyroptotic and apoptotic cell death in iNOS and nNOS overexpressing K562 cells: A mechanistic insight.
A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.This is relevant as gene–gene interactions must be taken into account in pharmacogenomics 25, 27-29. Supplementation may benefit those carrying the risk ‘T’ allele of T894G, especially those with elevated blood pressure or cardiovascular risk. By you using this site, you agree the information contained here is for informational purposes only. As providing citrus notes to perfumes and in skin creams and only link to vetted media sites university. Susceptibility to coronary spasm enzyme have attenuated nonexercising muscle vasodilatation in response to exercise conclusions: study. Is needed to help relax blood vessels and promotes blood clotting through the activation of platelets pathway... Orange is a co-factor required by NOS3 to function correctly 8 capacity to relax blood vessels and promotes blood through. 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